ribosomal S6 kinase-4 (ribosomal protein S6 kinase alpha 6, S6K-alpha 6, 90 kD ribosomal protein S6 kinase 6, p90-RSK 4, RSK-4, pp90RSK4, RPS6KA6)
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Function
- serine/threonine kinase
- may play a role in mediating the growth-factor & stress induced activation of the transcription factor CREB
- forms a complex with either ERK1 or ERK2 in quiescent cells, transiently dissociates following mitogenic stimulation
- activated by multiple phosphorylations on Thr & Ser (putative)
- autophosphorylated on Ser-389, as part of the activation process (putative)
Structure
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 2 protein kinase domains