ribosomal S6 kinase, 70kd, 2 (ribosomal protein S6 kinase beta 2, RPS6KB2, S6K-beta 2, 70 kDa ribosomal protein S6 kinase 2, p70-S6KB, p70 ribosomal S6 kinase beta, p70 S6Kbeta, S6K2, S6 kinase-related kinase, serine/threonine protein kinase 14 beta)

Function

• specifically phosporylates ribosomal protein S6
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Pathology

• may play a role in resistance to cancer chemotherapy

More general terms

• ribosomal protein S6 kinase

Database

• OMIM: https://mirror.omim.org/entry/608939
• UniProt: http://www.uniprot.org/uniprot/Q9UBS0.html