MAP kinase-interacting serine/threonine kinase 2 (MAP kinase signal-integrating kinase 2, MKNK2, GPRK7 MNK2)

Function

• may play a role in the response to environmental stress & cytokines
• appears to regulate transcription by phosphorylating EIF4E, thus increasing its affinity for the 7-methylguanosine- containing mRNA cap
• activated by dual phosphorylation of Thr-244 & Thr-249 &/or by phosphorylation of Thr-379
• interacts with the C-terminal regions of EIF4G1 & EIF4G2
• also binds to dephosphorylated ERK1 & ERK2
• isoform 2 interacts with ESR2

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2, binds 1 Zn+2 per subunit

Structure

• monomer
• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 1 protein kinase domain

Alternative splicing

named isoforms=5

Expression

• ubiquitously expressed in all tissues examined
• isoform 2 is expressed at higher levels in the ovary than is isoform 1

More general terms

• G protein-coupled receptor kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2872
• OMIM: https://mirror.omim.org/entry/605069
• UniProt: http://www.uniprot.org/uniprot/Q9HBH9.html