MAP kinase-interacting serine/threonine kinase 1 (MKNK1, MAP kinase signal-integrating kinase 1)

Function

• may play a role in the response to environmental stress & cytokines
• appears to regulate transcription by phosphorylating EIF4E, thus increasing its affinity for the 7-methylguanosine- containing mRNA cap
• interacts with the C-terminal regions of EIF4G1 & EIF4G2
• also binds to dephosphorylated ERK1 & ERK2, & to the p38 kinases
• phosphorylated & activated by the p38 kinases & kinases in the Erk pathway
• dual phosphorylation of Thr-250 & Thr-255 activates the kinase
• phosphorylation of Thr-385 activates the kinase

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• isoform 2: cytoplasm
• isoform 3: cytoplasm, nucleus

Alternative splicing

named isoforms=3

Expression

ubiquitous

More general terms

• G protein-coupled receptor kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8569
• OMIM: https://mirror.omim.org/entry/606724
• UniProt: http://www.uniprot.org/uniprot/Q9BUB5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8569