protein kinase A [PKA] catalytic subunit beta (PRKACB)

Function

• enzyme catalytic subunit of protein kinase A (PKA)
• mediates cAMP-dependent signaling triggered by receptor binding to GPCRs
• PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation & regulation of microtubule dynamics, chromatin condensation & decondensation, nuclear envelope disassembly & reassembly, as well as regulation of intracellular transport mechanisms & ion flux
• cAMP facilitates formation free monomeric catalytic subunits (active form of protein kinase A)

Cofactor: Mg+2

Structure

• Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB & CA respectively
• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Compartment

• cytoplasm (putative), nucleus
• translocates into the nucleus (monomeric catalytic subunit
• inactive holoenzyme is found in the cytoplasm (putative)

Alternative splicing

named isoforms=7

Expression

• isoform 1 is most abundant in the brain, low level expression in kidney
• isoform 2 is predominantly expressed in thymus, spleen & kidney
• isoforms 3 & 4 are only expressed in the brain

More general terms

• cAMP kinase

Additional terms

• protein kinase A

Database

• UniProt: http://www.uniprot.org/uniprot/P22694.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5567
• OMIM: https://mirror.omim.org/entry/176892