myotubularin-related protein 3; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; zinc finger FYVE domain-containing protein 10 (MTMR3, KIAA0371, ZFYVE10)

Function

• phosphatase
• acts on lipids with a phosphoinositol headgroup
• has phosphatase activity towards
  • phosphatidylinositol-3-phosphate
  • phosphatidylinositol-3,5-bisphosphate
• may also dephosphorylate proteins phosphorylated on Ser, Thr, & Tyr

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class myotubularin subfamily
• contains 1 FYVE-type Zn+2 finger
• contains 1 myotubularin phosphatase domain

Compartment

cytoplasm, membrane

Alternative splicing

named isoforms=3

More general terms

• myotubularin family protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8897
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8897
• OMIM: https://mirror.omim.org/entry/603558
• UniProt: http://www.uniprot.org/uniprot/Q13615.html