dual specificity protein phosphatase 22 (JNK-stimulatory phosphatase-1,JSP-1, mitogen-activated protein kinase phosphatase x, LMW-DSP2, DUSP22, JSP1, MKPX)

Function

• activates the Jnk signaling pathway
• dephosphorylates & deactivates MAP kinase p38 p38 & SAPK/JNK

Structure

• belongs to the protein-tyrosine phosphatase family, non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• highest expression in heart, placenta, lung, liver, kidney & pancreas

More general terms

• dual specificity phosphatase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NRW4.html