dual specificity protein phosphatase 18 (low molecular weight dual specificity phosphatase 20, DUSP18, LMWDSP20)

Function

• dual-specificity protein phosphatase
• can dephosphorylate single & diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine & diphosphorylated forms over phosphothreonine
• in vitro, dephosphorylates p-nitrophenyl phosphate (pNPP)
• activated by Mn+2
• inhibited by odoaretic acid

Kinetic parameters

• Optimum pH is 6.0
• Optimum temperature is 55 degrees C

Structure

• belongs to the protein-tyrosine phosphatase family
• non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm, nucleus

Expression

• widely expressed with highest levels in liver, brain, ovary & testis

More general terms

• dual specificity phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1502
• UniProt: http://www.uniprot.org/uniprot/Q8NEJ0.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=150290