protein tyrosine phosphatase 7, non-receptor type 7; stress-induced hematopoietic protein tyrosine phosphatase (PTPN7, HE-PTP)

Function

• protein phosphatase
• acts preferentially on tyrosine-phosphorylated MAPK1
• role in the regulation of T & B-lymphocyte development & signal transduction
• phosphorylated on Ser in resting T-cells
• phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels
• phosphorylation leads to dissociation of bound MAP kinases
• interacts with MAPK1, MAPK3 & several other MAP kinases

Structure

monomer

• belongs to the protein-tyrosine phosphatase family non-receptor class subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

expressed exclusively in thymus & spleen

More general terms

• tyrosine phosphatase, non-receptor type

Database

• UniProt: http://www.uniprot.org/uniprot/P35236.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5778
• OMIM: https://mirror.omim.org/entry/176889
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5778