probable serine protease HTRA3; high-temperature requirement factor A3; pregnancy-related serine protease (HTRA3 PRSP)

Function

• probable serine protease

Structure

• belongs to the peptidase S1B family
• contains 1 IGFBP N-terminal domain
• contains 1 Kazal-like domain
• contains 1 PDZ domain (DHR domain)

Compartment

secreted (putative)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest levels in both adult & fetal heart, ovary, uterus, placenta, & bladder
• isoform 1 is predominant in heart & skeletal muscle
• isoform 2 is predominant in placenta & kidney

More general terms

• serine protease
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94031
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:94031
• OMIM: https://mirror.omim.org/entry/608785
• UniProt: http://www.uniprot.org/uniprot/P83110.html