P2Y purinoceptor 8 (P2Y8, P2RY8)

Function

• probable receptor for purines coupled to G-proteins (purinoceptor)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• barely detectable in normal blood leukocytes
• weaker expression was seen in heart, kidney, lung
• not detected in brain
• down-regulated during granulocytic regulation

Genetics

• gene encoding for protein located in pseudoautosomal region 1 (PAR1) of X & Y chromosomes

More general terms

• G-protein coupled receptor; serpentine receptor
• purinoceptor

Database

• UniProt: http://www.uniprot.org/uniprot/Q86VZ1.html