G protein-coupled receptor 103; orexigenic neuropeptide QRFP receptor; pyroglutamylated RFamide peptide receptor (SP9155, AQ27, QRFPR, GPR103)

Function

• receptor for the orexigenic neuropeptide QRFP
  • activity is mediated by G proteins that modulate adenylate cyclase activity & intracellular Ca+2 levels

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• expressed widely in the brain
  • high levels in the hypothalamus, trigeminal ganglia & vestibular neurons
  • moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus & medulla oblongata. I
• in peripheral tissues, expressed at high levels in the retina > heart, kidney, testis & thyroid

More general terms

• G-protein coupled receptor; serpentine receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84109
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84109
• OMIM: https://mirror.omim.org/entry/606925
• UniProt: http://www.uniprot.org/uniprot/Q96P65.html