G-protein coupled receptor 64; human epididymis-specific protein 6; He6 (GPR64, HE6, TM7LN2)

Function

• could be involved in a signal transduction pathway controlling epididymal function & male fertility
• proteolytically cleaved into 2 subunits, an extracellular subunit & a seven-transmembrane subunit (putative)
• forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety (probable)

Structure

• belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
• contains 1 GPS domain

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=9

Expression

• epididymis specific
• both subunits are associated with apical membranes of efferent ductule & proximal epididymal duct epithelia

More general terms

• G-protein coupled receptor; serpentine receptor
• phosphoprotein

Additional terms

• epididymis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10149
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10149
• OMIM: https://mirror.omim.org/entry/300572
• UniProt: http://www.uniprot.org/uniprot/Q8IZP9.html