nicotinic acid receptor 1; G-protein coupled receptor 109A; G-protein coupled receptor HM74A (GPR109A, HCAR2, HM74A)

Function

• high affinity receptor for nicotinic acid
• mediates its anti-lipolytic effect through a Gi protein- mediated inhibition of adenylyl cyclase
• pharmacological effect requires nicotinic acid doses much higher than those provided by a normal diet

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

membrane

Expression

largely restricted to adipose tissue & spleen

More general terms

• G-protein coupled receptor; serpentine receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3384
• UniProt: http://www.uniprot.org/uniprot/Q8TDS4.html