retinoic acid induced 3 protein (G protein-coupled receptor family C group 5 member A, retinoic acid induced gene 1 protein, RAIG-1, orphan G protein-coupling receptor PEIG-1, RAI3, GPRC5A, RAIG1)

Function

• unknown.
• G-protein coupled receptor
• may play role in modulating differentiation & maintaining homeostasis of epithelial cells
• possible role in embryonic development & maturation of these kidney & lung
• retinoic acid-inducible

Structure

belongs to the G-protein coupled receptor 3 family

Compartment

• cell membrane
• cytoplasmic vesicle membrane
• localized in the plasma membrane & perinuclear vesicles

Expression

• expressed at high level in fetal & adult lung tissues
• constitutively expressed in fetal kidney & adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, & spinal cord at low to moderate levels
• not detectable in fetal heart, brain, & liver & adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, & peripheral leukocytes
• induced by all-trans retinoic acid (ATRA)

More general terms

• G-protein coupled receptor; serpentine receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9052
• OMIM: https://mirror.omim.org/entry/604138
• UniProt: http://www.uniprot.org/uniprot/Q8NFJ5.html