smoothened homolog; SMO; Gx protein (SMO, SMOH)

Function

• G protein-coupled receptor
• probably associates with patched (PTCH) to transduce hedgehog's signal
• binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened

Structure

• belongs to the G-protein coupled receptor Fz/smo family
• contains 1 FZ (frizzled) domain

Compartment

membrane

Pathology

• defects in SMO are involved in basal cell carcinoma

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6608
• OMIM: https://mirror.omim.org/entry/601500
• UniProt: http://www.uniprot.org/uniprot/Q99835.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6608