TBC1 domain family member 10C; carabin (TBC1D10C)
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Function
- inhibits Ras signaling pathway through its intrinsic Ras-GAP activity
- negative feedback inhibitor of the calcineurin signaling
- mediates crosstalk between calcineurin & Ras
- interacts with both calcineurin & HRAS
Structure
contains 1 Rab-GAP TBC domain
Expression
most abundant in spleen & peripheral blood leukocytes