single-minded homolog 2; class E basic helix-loop-helix protein 15; bHLHe15 (SIM2 BHLHE15)

Function

• transcription factor
• may be a master gene of CNS development in cooperation with ARNT
• may have pleiotropic effects in the tissues expressed during development
• efficient DNA binding requires dimerization with another bHLH protein
• heterodimer of SIM2 & ARNT

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 2 PAS (PER-ARNT-SIM) domains
• contains 1 single-minded C-terminal domain

Compartment

nucleus

Alternative splicing

named isoforms=2; SIM2, SIM2S

More general terms

• single-minded homolog

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6493
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6493
• OMIM: https://mirror.omim.org/entry/600892
• UniProt: http://www.uniprot.org/uniprot/Q14190.html