neurogenin-3; NGN-3; class A basic helix-loop-helix protein 7; bHLHa7; protein atonal homolog 5 (NEUROG3 ATOH5 BHLHA7 NGN3)

Function

• acts as a transcriptional regulator
• together with NKX2-2, initiates transcriptional activation of NEUROD1
• role in neurogenesis
• also required for the specification of a common precursor of the 4 pancreatic endocrine cell types
• efficient DNA binding requires dimerization with another bHLH protein (putative)

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus (putative)

Pathology

• defects in NEUROG3 are the cause of hereditary diarrhea type 4

More general terms

• neurogenin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50674
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50674
• OMIM: https://mirror.omim.org/entry/604882
• OMIM: https://mirror.omim.org/entry/610370
• UniProt: http://www.uniprot.org/uniprot/Q9Y4Z2.html