POU domain class 4, transcription factor 3; brain-specific homeobox/POU domain protein 3C; POU domain transcription factor BRN3C (POU4F3)

Function

• may play a role in determining or maintaining the identities of a small subset of visual system neurons

Structure

• belongs to the POU transcription factor family, class-4 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

nucleus

Expression

brain. seems to be specific to the retina

Pathology

• defects in POU4F3 are the cause of non-syndromic autosomal dominant sensorineural deafness 15

More general terms

• POU protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5459
• OMIM: https://mirror.omim.org/entry/602459
• OMIM: https://mirror.omim.org/entry/602460
• UniProt: http://www.uniprot.org/uniprot/Q15319.html