POU domain, class 3, transcription factor 4; brain-specific homeobox/POU domain protein 4; brain-4; Brn-4; octamer-binding protein 9; Oct-9; octamer-binding transcription factor 9; OTF-9 (POU3F4, BRN4, OTF9)

Function

• probable transcription factor
• wide role during early neural development & in a very limited set of neurons in the mature brain (putative)

Structure

• belongs to the POU transcription factor family, class-3 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

nucleus

Expression

brain specific

Pathology

• defects in POU3F4 are a cause of X-linked deafness type 2

More general terms

• POU protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5456
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5456
• OMIM: https://mirror.omim.org/entry/300039
• OMIM: https://mirror.omim.org/entry/304400
• UniProt: http://www.uniprot.org/uniprot/P49335.html