homeobox-containing protein 1 (HMBOX1)

Function

• transcription factor
• isoform 1 acts as a transcriptional repressor
• isoform 4 has very low activity as a transcriptional repressor

Structure

contains 1 homeobox DNA-binding domain

Compartment

• nucleus, cytoplasm
• predominantly detected in cytoplasm

Alternative splicing

named isoforms=5

Expression

• ubiquitous
• detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, & colon

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79618
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79618
• UniProt: http://www.uniprot.org/uniprot/Q6NT76.html