T-cell leukemia homeobox protein 2; homeobox protein Hox-11L1; neural crest homeobox protein (TLX2, HOX11L1, NCX)

Function

• transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'
• binds DNA via its homeobox
• required for normal cell death of enteric neurons in the gastrointestinal tract
• required for normal development of the enteric nervous system, & for proper development of normalmotility of the gastrointestinal tract (putative)

Structure

• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3196
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3196
• OMIM: https://mirror.omim.org/entry/604240
• UniProt: http://www.uniprot.org/uniprot/O43763.html