paired mesodermal homeobox protein 1; PHOX1; paired related homeobox protein 1; PRX-1 (PRRX1, PMX1)

Function

• transcriptional regulator of muscle creatine kinase
• role in establishment of diverse mesodermal muscle types
• binds to an A/T-rich element in the muscle creatine enhancer (putative)

Structure

• belongs to the paired homeobox family
• contains 1 homeobox DNA-binding domain
• contains 1 OAR domain

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• homeobox protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5396
• OMIM: https://mirror.omim.org/entry/167420
• UniProt: http://www.uniprot.org/uniprot/P54821.html