homeobox protein-11; HOX-11; TCL-3 proto-oncogene protein; T-cell leukemia homeobox protein 1; T-cell leukemia/lymphoma protein 3; proto-oncogene TCL-3; TLX1 (HOX11, TCL3)

Function

• controls genesis of the spleen
• binds to the DNA sequence 5'-GGCGGTAAGTGG-3'

Structure

contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Pathology

• chromosomal translocation t(10;14)(q24;q11) involving TLX1 with TCRD may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL)

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P31314.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3195
• OMIM: https://mirror.omim.org/entry/186770