ATP-binding cassette transporter sub-family C member 11; multidrug resistance-associated protein 8 (ABCC11, MRP8)

Function

• metabolism of bile acids, conjugated steroids & cyclic nucleotide
• enhances the cellular extrusion of cAMP & cGMP
• stimulates the ATP-dependent uptake lipophilic anions
  • glutathione S-conjugates
    • leukotriene C4
  • steroid sulfates
    • dehydroepiandrosterone 3-sulfate (DHEAS)
    • estrone 3-sulfate
  • glucuronides
    • estradiol 17-beta-D-glucuronide
  • monoanionic bile acids
    • glycocholate
    • taurocholate
  • methotrexate
  • secretion of earwax (putative)

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains
• contains 2 ABC transporter domains

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in breast, testis > liver, brain, placenta
• not expressed in kidney, spleen, colon
• highly expressed in breast cancer

Polymorphism

• allele with Arg-184 is responsible for the dry earwax phenotype

More general terms

• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
• transmembrane 10 protein

Database

• OMIM: https://mirror.omim.org/entry/607040
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85320
• UniProt: http://www.uniprot.org/uniprot/Q96J66.html