canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; multidrug resistance-associated protein 3; multi-specific organic anion transporter D; MOAT-D (ABCC3, CMOAT2, MLP2, MRP3)

Function

• may act as an inducible transporter in the biliary & intestinal excretion of organic anions
• acts as an alternative route for the export of bile acids & glucuronides from cholestatic hepatocytes (putative)

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains; residues 311594 & 971-1252
• contains 2 ABC transporter domains; residues 629-851 & 1323-1330

Compartment

membrane

Alternative splicing

named isoforms=4

additional isoforms seem to exist

some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense- mediated mRNA decay

Expression

• mainly expressed in the liver
• also expressed in small intestine, colon, prostate, testis, brain & at a lower level in the kidney

More general terms

• transmembrane 17 protein
• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8714
• OMIM: https://mirror.omim.org/entry/604323
• UniProt: http://www.uniprot.org/uniprot/O15438.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8714