ATP-binding cassette sub-family B member 5 (P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5, MDR/TAP)

Function

• plasma membrane transporter
• efflux xenobiotics from cells (rhodamine dye, doxorubicin)

Structure

• belongs to the ABC transporter family, MDR subfamily
• contains 1 ABC transmembrane type-1 domain
• contains 2 ABC transporter domains

Compartment

• cell membrane

Alternative splicing

named isoforms=2

Expression

• expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level)

widely expressed with specific expression in pigment cells

Pathology

• expressed in several malignant tissues
• role in resistance to doxorubicin of a subset of malignant melanomas
• depletion of ABCB5 by RNAi increases sensitivity to several drugs of a subset of melanoma cells

More general terms

• transmembrane 5 protein
• ATP-binding cassette sub-family B (ABC transporter-B, ABCB)

Additional terms

• P-glycoprotein (gp170) or multidrug-resistance glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=340273
• UniProt: http://www.uniprot.org/uniprot/Q2M3G0.html