calpain-10 catalytic subunit (digestive tract-specific calpain, nCL-4, CG36 protein, CAPN9, NCL4)

Function

• Ca+2-regulated non-lysosomal thiol-protease
• broad endopeptidase specificity

Structure

• belongs to the peptidase C2 family
• contains 1 calpain catalytic domain
• contains 3 EF-hand domains

Alternative splicing

named isoforms=2

Expression

expressed predominantly in stomach

Pathology

• down-regulated in gastric cancer tissue & in gastric cell lines of differentiated & poorly differentiated types

More general terms

• calpain catalytic or large subunit

Component of

• calpain-9

Database

• OMIM: https://mirror.omim.org/entry/606401
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1075
• UniProt: http://www.uniprot.org/uniprot/O14815.html