calpain-2 catalytic [large] subunit (calpain large polypeptide L2, CAPN2)

Function

• Ca+2-regulated non-lysosomal thiol-protease
• catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling & signal transduction
• forms a heterodimer with a small (regulatory) subunit (CAPNS1)
• activated by 200-1000 uM concentrations of Ca+2
• inhibited by calpastatin
• broad endopeptidase specificity

Cofactor: binds 3 Ca+2

Structure

• belongs to the peptidase C2 family
• contains 1 calpain catalytic domain
• contains 4 EF-hand domains

Compartment

• cytoplasm (putative)
• cell membrane
• translocates to the plasma membrane upon Ca+2 binding (putative)

Expression

ubiquitous

More general terms

• calpain catalytic or large subunit

Component of

• calpain-2 or calcium-activated neutral protease-M type

Database

• UniProt: http://www.uniprot.org/uniprot/P17655.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:824;
• OMIM: https://mirror.omim.org/entry/114230
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=824