geranylgeranyltransferase-beta 1 (PGGT1B)
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Function
- catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a Cys at the 4th position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X
- acts on the Rac1, Rac2, Rap1A & Rap1B proteins
- the beta subunit is responsible for peptide-binding
geranylgeranyl diphosphate + protein-cysteine
<-->
S-geranylgeranyl-protein + diphosphate
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure
- heterodimer of an alpha & a beta subunit
- belongs to the protein prenyltransferase subunit beta family
- contains 4 PFTB repeats
Alternative splicing
named isoforms=2
More general terms
Component of
References
- ↑ Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20189751
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ UniProt http://www.uniprot.org/uniprot/P53609.html