geranylgeranyltransferase-1 (GGTase-1)
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Function
- transfers C-20 isoprenyl moiety via pyrophosphate
- prefers Leu as X of CaaX motif
Structure
- heterodimer of an alpha & a beta subunit
More general terms
References
- ↑ Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell. 1990 Jul 13;62(1):81-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2194674
- ↑ Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20189751
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209