nucleoside diphosphate kinase-6 (NDP kinase 6, nm23-H6, NME6, inhibitor of p53-induced apoptosis-alpha, IPIA-alpha)

Function

• major role in the synthesis of nucleoside triphosphates other than ATP
• ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
• inhibitor of p53-induced apoptosis

ATP + nucleoside diphosphate <-->  ADP + nucleoside triphosphate

Cofactor: Mg+2 (putative)

Structure

belongs to the NDK family

Expression

• expressed at a moderately low level in many tissues
• most abundant in kidney, prostate, ovary, intestine, & spleen

More general terms

• nucleoside diphosphate kinase (NDK) or NDP kinase

Database

• OMIM: https://mirror.omim.org/entry/608294
• UniProt: http://www.uniprot.org/uniprot/O75414.html