cytochrome P450 3A43 (CYP3A43)

Function

• low testosterone 6-beta-hydroxylase activity

Structure

belongs to the cytochrome P450 family

Compartment

membrane-bound, endoplasmic reticulum

Alternative splicing

named isoforms=5

Expression

• prostate > liver, kidney, pancreas, fetal liver, fetal skeletal muscle
• induced by rifampicin

Polymorphism

• alleles are known, CYP3A43*1, CYP3A43*2, CYP3A43*3
• CYP3A43*1 most frequent allele
• CYP3A43*2 likely to be non-functional

More general terms

• cytochrome P450 3A (CYP3A)

Database

• OMIM: https://mirror.omim.org/entry/606534
• UniProt: http://www.uniprot.org/uniprot/Q9HB55.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64816