UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1 (UXS1)

Function

• catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose
• biosynthesis of core tetrasaccharide in glycosaminoglycans
• glycosylation pathway
• interacts with AKT1

UDP-D-glucuronate <--> UDP-D-xylose + CO2

Cofactor: NAD

Structure

• belongs to the sugar epimerase family, UDP-glucuronic acid decarboxylase subfamily

Compartment

• Golgi
• single-pass type 2 membrane protein (putative)

Alternative splicing

named isoforms=3

More general terms

• carboxy-lyase or decarboxylase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80146
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80146
• OMIM: https://mirror.omim.org/entry/609749
• UniProt: http://www.uniprot.org/uniprot/Q8NBZ7.html