peptidyl-prolyl cis-trans isomerase-like 1 (PPIase, rotamase, PPIL1, CYPL1, CGI-124, UNQ2425/PRO4984)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
• role in pre-mRNA splicing, component of spliceosome C complex

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Inhibition:

• inhibited by Cyclosporin A

Kinetic parameters:

• KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilid

Structure

• belongs to the cyclophilin-type PPIase family, PPIL1 subfamily
• contains 1 PPIase cyclophilin-type domain

Expression

• ubiquitous, most abundant in heart & skeletal muscle

More general terms

• peptidyl-prolyl cis/trans isomerase (PPIase) or rotamase

Component of

• spliceosome C complex

Database

• OMIM: https://mirror.omim.org/entry/601301
• UniProt: http://www.uniprot.org/uniprot/Q9Y3C6.html