peptidyl-prolyl cis-trans isomerase-like 1 (PPIase, rotamase, PPIL1, CYPL1, CGI-124, UNQ2425/PRO4984)
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Function
- PPIases accelerate the folding of proteins
- catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
- role in pre-mRNA splicing, component of spliceosome C complex
peptidylproline (omega=180) <--> peptidylproline (omega=0)
Inhibition:
- inhibited by Cyclosporin A
Structure
- belongs to the cyclophilin-type PPIase family, PPIL1 subfamily
- contains 1 PPIase cyclophilin-type domain
Expression
- ubiquitous, most abundant in heart & skeletal muscle