beta-galactoside alpha-2,6-sialyltransferase 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; alpha 2,6-ST 2; monosialoganglioside sialyltransferase; ST6gal II; ST6gal-II; ST6galII; hST6gal II (ST6GAL2, KIAA1877, SIAT2)

Function

• transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates
• alpha-2,6-sialyltransferase activity toward oligosaccharides that have the gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups
• weak or no activities toward glycoproteins & glycolipids

CMP-N-acetylneuraminate +  beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine <--> CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4- N-acetyl-beta-D-glucosamine

Kinetic parameters:

• KM=0.74 mM for gal-beta-1,4-GlcNAc-beta-O-octyl
• KM=0.71 mM for gal-beta-1,4-GlcNAc
• KM=0.48 mM for lacto-N-neotetraose

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

Expression

• weakly expressed in some tissues, including small intestine, colon & fetal brain
• induced by IL6 & IL8

More general terms

• sialyltransferase
• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/608472
• UniProt: http://www.uniprot.org/uniprot/Q96JF0.html