cholinephosphotransferase 1 (diacylglycerol cholinephosphotransferase 1, hCPT1, AAPT1-like protein, CHPT1, CPT1, MST022)

Function

• catalyzes phosphatidylcholine biosynthesis from CDP-choline
• role in the formation & maintenance of vesicular membranes

CDP-choline + 1,2-diacylglycerol <--> CMP + phosphatidylcholine

Cofactor: Mg+2 or Mn+2

Structure

• belongs to the CDP-alcohol phosphatidyltransferase class-I family

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

Expression

• expressed in testis, colon, small intestine, heart, prostate, spleen > kidney, skeletal muscle, pancreas, leukocytes, ovary, thymus > brain, placenta, lung

Pathology

• overexpressed in cancerous breast epithelial cell lines

More general terms

• phosphotransferase
• transmembrane 8 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WUD6.html