phosphoribosylglycinamide formyltransferase (phosphoribosylformylglycinamidine cyclo-ligase, trifunctional purine biosynthetic protein adenosine-3, phosphoribosylglycinamide synthetase, GART)

Function

• nucleotide biosynthesis; IMP biosynthesis
• phosphoribosylglycinamide formyltransferase is part, with phosphoribosylformyl-glycinamidine cyclo-ligase (AIRS) & with phospho-ribosylglycinamide synthetase (GARS) of a trifunctional enzyme (GARS-AIRS-GART)
• GARS-AIRS-GART catalyzes 3 steps in the de novo biosynthesis of purine
• N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2
• nucleotide biosynthesis; IMP biosynthesis; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/5
• nucleotide biosynthesis; IMP biosynthesis; N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1
• context: purine biosynthesis

ATP + 5-phospho-D-ribosylamine + glycine
                 <-->
ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine
                 <-->
ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide
                        <-->
tetrahydrofolate + N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide

Structure

• in N-terminal section, belongs to the GARS family
• contains 1 ATP-grasp domain
• in the central section, belongs to the AIR synthase
• in the C-terminal section, belongs to the GART family

Alternative splicing

named isoforms=2

More general terms

• acyltransferase

Additional terms

• glycyl-tRNA synthetase (glycine-tRNA ligase, glyRS, GARS)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2618
• UniProt: http://www.uniprot.org/uniprot/P22102.html
• OMIM: https://mirror.omim.org/entry/138440