dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase (mannosyltransferase ALG12 homolog, hALG12, membrane protein SB87, ALG12)

Function

• required for protein glycosylation
• adds the 8th mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2))

Structure

• belongs to the glycosyltransferase 22 family

Compartment

• endoplasmic reticulum

Expression

• expressed in fibroblasts

Pathology

• defects in ALG12 are the cause of congenital disorder of glycosylation type Ig

More general terms

• glycosyltransferase
• transmembrane 12 protein

Additional terms

• protein glycosylation

Database

• OMIM: https://mirror.omim.org/entry/607143
• OMIM: https://mirror.omim.org/entry/607144
• UniProt: http://www.uniprot.org/uniprot/Q9BV10.html