protein N-terminal asparagine amidohydrolase; protein NH2-terminal asparagine amidohydrolase; PNAA; protein NH2-terminal asparagine deamidase; PNAD; protein N-terminal Asn amidase; protein NTN-amidase (NTAN1)

Function

• side-chain deamidation of N-terminal Asn to Asp
• ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn
  • these proteins are acetylated on the retained initiator Met & can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH)
  • conversion of the resulting N-terminal Asn to Asp by PNAD renders the protein susceptible to arginylation, polyubiquitination & degradation as specified by the N-end rule
• does NOT act on substrates with internal or C-terminal Asn
• does NOT act on Gln residues in any position

Structure

monomer

Compartment

cytoplasm (putative)

More general terms

• amidohydrolase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=123803
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:123803
• UniProt: http://www.uniprot.org/uniprot/Q96AB6.html