biliverdin reductase A, adult (BLVRA, biliverdin IX-alpha reductase)

Function

• reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor
• porphyrin metabolism; protoheme degradation

bilirubin + NAD+/NADP+ <-->  biliverdin + NADH/NADPH

Cofactor: binds 1 Zn+2 per subunit

Structure

• monomer
• belongs to the gfo/idh/mocA family, biliverdin reductase subfamily

Compartment

cytoplasm

Expression

liver

Notes

• uses NADH or NADPH depending on the pH
• NADH is used at the acidic pH range (6-6.9) & NADPH at the alkaline range (8.5-8.7)
• NADPH is the probable reactant in biological systems

More general terms

• biliverdin reductase

Database

• OMIM: https://mirror.omim.org/entry/109750
• UniProt: http://www.uniprot.org/uniprot/P53004.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:644