quinone oxidoreductase PIG3; tumor protein p53-inducible protein 3; p53-induced gene 3 protein (TP53I3, PIG3)

Function

• may be involved in generation of reactive oxygen species (ROS)
• low NADPH-dependent naphtoquinone reductase activity, with a preference for 1,2-naphtoquinone over 1,4-naphtoquinone
• has low NADPH-dependent diamine reductase activity (in vitro)

Kinetic parameters:

• KM=215 uM for 1,2-naphtoquinone

Structure

• homodimer
• belongs to the Zn+2-containing alcohol dehydrogenase family, quinone oxidoreductase subfamily

Alternative splicing

• named isoforms=2
• isoform 1: major isoform under normal light conditions
• isoform 2:
  • UV radiation favors the production of isoform 2
  • rapid proteolytic degradation by the proteasome

Expression

• isoform 1 & isoform 2 are both activated by TP53/p53, doxorubicin, etoposide & ionizing radiation
• isoform 2 is highly activated by UV radiation

More general terms

• quinone reductase
• apoptosis stimulating protein of p53; p53-binding protein (ASPP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9540
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9540
• OMIM: https://mirror.omim.org/entry/605171
• UniProt: http://www.uniprot.org/uniprot/Q53FA7.html