hydroxysteroid dehydrogenase-like protein 1 (HSDL1)
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Structure
- belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily
- although related to the SDR family, lacks the conserved active Tyr residue in position 218 which is replaced by Phe, suggesting that it may lack oxidoreductase activity
Expression
- highly expressed in testis & ovary
- detected in thyroid, spinal cord, adrenal gland, heart, placenta, skeletal muscle & pancreas