17 beta-hydroxysteroid dehydrogenase-3 [testicular] (estradiol 17 beta-dehydrogenase 3, HSD17B3)

Function

• testosterone biosynthesis; last step
• reduction of androstenedione to testosterone (uses NADPH)
• interconverts 17-beta estradiol & estrone

Expression

expressed in testis

Pathology

• defects in HSD17B3 result in male pseudohermaphrodism with gynecomastia

More general terms

• 17 beta-hydroxysteroid dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/P37058.html
• OMIM: https://mirror.omim.org/entry/264300