prostaglandin reductase 1; PRG-1; 15-oxoprostaglandin 13-reductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase (PTGR1, LTB4DH)

Function

• 15-oxo-prostaglandin 13-reductase
• substrates include 15-oxo-PGE1, 15-oxo-PGE2 & 15-oxo-PGE2-alpha
• no activity towards PGE1, PGE2 & PGE2-alpha (putative)
• catalyzes conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4
• monomer or homodimer (putative)

Structure

• belongs to the NADP-dependent oxidoreductase L4BD family

Compartment

cytoplasm

Expression

• high expression in the kidney, liver, & intestine
• lesser expression if any in leukocytes

More general terms

• dehydrogenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22949
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22949
• OMIM: https://mirror.omim.org/entry/601274
• UniProt: http://www.uniprot.org/uniprot/Q14914.html