NADPH-dependent carbonyl reductase; prostaglandin-E2 9-reductase; 15-hydroxyprostaglandin dehydrogenase [NADP+] (CBR1, CBR, CRN)

Function

• catalyzes reduction of a wide variety of carbonyl compounds including antitumor anthracycline antibiotics
• can convert prostaglandin E2 to prostaglandin F2-alpha

R-CHOH-R' + NADP+ <-->  R-CO-R' + NADPH

(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate
+ NADP+
     <-->
(5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
+ NADPH

(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+
      <-->
(13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH

Structure

• monomer
• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

cytoplasm

More general terms

• dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/P16152.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:873
• OMIM: https://mirror.omim.org/entry/114830