thioredoxin-1 (ATL-derived factor, ADF, surface-associated sulfhydryl protein, SASP, TRX1, TXN, TRDX)

Function

• role in redox reactions through reversible oxidation of its active center dithiol to a disulfide
• catalyzes dithiol-disulfide exchange reactions
• augments expression of IL2 receptor TAC (IL2R/P55)

Structure

• homodimer
• interacts with TXNIP through the redox-active site
• belongs to the thioredoxin family
• contains 1 thioredoxin domain

Compartment

cytoplasm

More general terms

• thioredoxin-1 (TRX)

Additional terms

• thioredoxin domain-containing protein
• thioredoxin-like protein

Database

• UniProt: http://www.uniprot.org/uniprot/P10599.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7295
• OMIM: https://mirror.omim.org/entry/187700