contactin-6 (neural recognition molecule NB-3, hNB-3, CNTN6)

Function

• contactins mediate cell surface interactions during nervous system development
• role in oligodendrocyte generation by acting as a ligand of NOTCH1
• association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) & subsequent translocation to the nucleus
• role in motor coordination

Structure

• belongs to the immunoglobulin superfamily, contactin family
• contains 4 fibronectin F3 modules
• contains 6 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• cell membrane, GPI-anchor

Expression

• expressed in nervous system
• expressed in cerebellum > thalamus, subthalamic nucleus > corpus callosum, caudate nucleus, spinal cord

More general terms

• contactin

Database

• OMIM: https://mirror.omim.org/entry/607220
• UniProt: http://www.uniprot.org/uniprot/Q9UQ52.html