cornifin-A; small proline-rich protein IA; SPR-IA; SPRK; 19 kD pancornulin (SPRR1A)

Function

• cross-linked envelope protein of keratinocytes
• first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
• all that results in the formation of an insoluble envelope beneath the plasma membrane

Structure

belongs to the cornifin (SPRR) family

Compartment

cytoplasm

Expression

• during squamous differentiation of epidermal keratinocytes

More general terms

• cornifin or small proline-rich protein-1 (SPR-1)

Additional terms

• cornifin-B; small proline-rich protein IB; SPR-IB; 14.9 kD pancornulin (SPRR1B)

Database

• UniProt: http://www.uniprot.org/uniprot/P35321.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6698
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6698
• OMIM: https://mirror.omim.org/entry/182265